- Fridge Logic: George initially believing Beethoven bit the vet makes sense when you consider Beethoven is a large, male, unneutered and ill-behaved dog.
- Retroactive Recognition: In the first movie, look out for a pre-Everybody Loves Raymond Patricia Heaton and a pre-The X-Files David Duchovny as a pair of con artists who try con George out of his air freshener business.
- In addition, in the second movie, a pre-That 70s Show Danny Masterson appears as Ryce's boyfriend.
- Unacceptable Targets: The American Veterinary Association wrote a letter to the head of the MPAA (Jack Valenti) about the main villain of the first film being a veterinarian.
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