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- Hey, It's That Guy!:
- Peter Scolari, who co-starred with Tom Hanks in Bosom Buddies, as the host of the nationally broadcast television show (a stand-in for The Ed Sullivan Show).
- Kevin Pollak as Pittsburgh DJ 'Boss' Vic Koss.
- Clint Howard as a jazz radio DJ (his claims to fame include cameos in films by his brother Ron Howard, the alien Balok from the Star Trek: The Original Series episode "The Corbomite Maneuver", and many roles as Mission Control - including Apollo 13).
- Chris Isaak as Guy's Uncle Bob, who makes their recording.
- Charlize Theron, in only her third film role, as Guy's hometown girlfriend Tina.
- Walter White, the famed astronaut.