In Spoilsbury Toast Boy, the doctor beetle explains to Liache that "mucus is a living thing" and "it has a certain degree of intelligence." The beetles later drown Liache when her mucus tells them she doesn't deserve to breathe.
In the Global Guardians PBEM Universe, while intelligent apes have been given full civil rights, robots, androids, and other artificial intelligences are still not considered people in the legal sense even though they cannot be harmed with impunity (property laws come into consideration). Demons, the undead, and most other forms of monster are free targets, however.
Deconstructed in this Video Game Confessions which reimagines Samus as a violent torturer and serial killer. She asks "Why is it that when you kill an alien from another world, you're considered a hero?"